Novel linear IgE-binding peptide epitopes of the major celery allergen api g1 have been identified which are suitable for the diagnosis and therapy of celery allergy. The peptide epitopes can also serve as a basis for the detection of api g1 allergens in food and other products. Based on the novel peptides, a high specific assay was developed which allows to distinguish between celery allergic patients and healthy individuals.Celery is a frequent cause of food allergy in pollen-sensitized patients and may induce severe allergic reactions. Allergic reactions against celery are of major clinical relevance due to celery's wide presence in convenience foods and spice. Approximately 3% - 4% of the European or American population and 5% of young children are affected by immunoglobulin E (IgE) mediated food allergy; 30% of them are sensitized to celery. The symptoms ranging from mild oral pruritus to a possible life-threatening anaphylactic shock.
IP Rights
An EP application was filed in July 2010.
Origin
The invention was made at the Charité – Universitätsmedizin Berlin.
