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A Stable Cell Line that is Inducible to Express hsTRPM2


29.10.2009 | Ref.Nr. 08135
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Life Science › Pharma&Biotech

The transient receptor potential melastanin-related 2 (TRPM2) channel functions as a central connective element between oxidative stress and intracellular calcium homeostasis. In contrast to other TRP-cation channels, TRPM2 has its own specific pharmacology that cannot be inhibited by known, non-selective, inorganic TRP-cation channel blockers. Therefore a method is needed that enables an effective screening for new TRPM2 blockers.

To meet the needs the inventors established a stable, TRPM2-expressing mammal cell line that expresses the cation channel TRPM2 in an inducible way. Thus the modified cell line offers a methodology for the identification of new and improved TRPM-2 channel inhibitors and activators. The cell line used for TRPM2 cloning is the commercially available Flip-In T-Rex 293 cell line.

 

Origin
The cell line was created at the Charité – Universitätsmedizin Berlin.

Application Area:
Pharma
Development Stage: Product
Type of Collaboration: License
Schlagworte: Calcium Homeostasis, Cell, Oxidative Stress, Pharmacology, TRPM2,
Weitere Kategorien: Diagnostics, Life Science, CNS & Neurology, CNS & Neurology, Pharma & Biotech
Bild des Benutzers Rafaela Kunz
Licensing Manager: Rafaela Kunz
T +49 30 2125 4825
F +49 30 2125 4822
rafaela.kunz@ipal.de
Market Potential: Worldwide
Benefits:
  • Stable cell line
  • TRPM2 expression can be controlled and induced
  • Allows effective screening for TRPM2 blockers
  • Wide application field (Identification of activators and inhibitors of the TRP-cation channels, Identification of TRPM2-Targets that might be useful as: Asthma therapeutics, Immunotherapeutics, Therapeutics in the therapy of neurodegenerative diseases (e.g. Multiple Sclerosis, Alzheimer’s Disease, Parkinson's Disease)